Tunisia, South Africa, Gabon and Uganda also booked their places in the Africa Cup of Nations 2025.
Victor Osimhen scored twice as Galatasaray inflicted a first Europa League defeat of the season on Tottenham with a 3-2 victory in Istanbul on Thursday, while Manchester United got their first win on the board by beating PAOK Thessaloniki.
Nigeria forward Victor Osimhen rolled home the leveller with 15 minutes left of the first leg of their Champions League last 16 tie at the Stadio Diego Armando Maradona.
Victor Osimhen levelled in the first half almost immediately after Iban Edu had opened the scoring for Equatorial Guinea.
Khvicha Kvaratskhelia swept home the decisive strike in the 75th minute, six minutes after Victor Osimhen's headed opener and shortly after Leonardo Pavoletti had equalised for the away side.
Napoli reached the last 16 of the Champions League on Tuesday after seeing off Braga 2-0 and ending a home hoodoo which had stretched back more than two months.
Record 14-time champions Real Madrid were already through but secured top spot with an entertaining win over the visiting Italian champions
Victor Osimhen removed photos of himself in Napoli colours from his own social media, fuelling speculation that he will demand a move in the next transfer window.
Victor Osimhen's agent has threatened legal action against Napoli after a video was published on the club's official social media mocking the Nigeria striker for missing a penalty in the weekend's goalless draw at Bologna.
The 24-year-old is now the highest scoring African player in the history of Serie A after overtaking George Weah and lapped up the applause of Napoli fans as the team did their post-match lap of honour.