Juventus on Monday confirmed that Paulo Dybala suffered a thigh injury in their match against Sampdoria on Sunday.
Juventus outclassed Lecce 4-0 thanks to goals from Paulo Dybala, Cristiano Ronaldo, Gonzalo Higuain and Matthijs de Ligt.
Juventus beat Bologna 2-0 win to move four points clear of Lazio on top of the Serie A table.
Paulo Dybala was diagnosed on March 22, along with his girlfriend Oriana, who recovered sooner from the disease which has killed nearly 30,000 people in Italy.
Paulo Dybala spoke about how he would not be able to move around for more than five minutes as he would not be able to breathe and his muscles would hurt.
Paulo Dybala is the 3rd Juventus player to test positive for coronavirus while former AC Milan defender Paolo Maldini revealed that he and his son have also been infected.
Lyon midfielder Lucas Tousart netted in the 31st minute to give Lyon a lead to defend when they head to Turin for the return leg on March 17.
Cristiano Ronaldo looked glum as he came off and directed some words at coach Maurizio Sarri before heading to the changing rooms.
Inter Milan vs Juventus: Defending Serie A champions moved one point ahead of Inter after 7 games as they target a 9th consecutive title, and first under Maurizio Sarri.
Kalidou Koulibaly scored an own goal in the second minute of stoppage time to hand Juventus the three points in Turin.
Massimiliano Allegri held meetings with Juventus' hierarchy earlier in the week during which a clear disagreement between the two parties emerged.
Moise Kean, 19, came on as a substitute in Turin and three minutes later scored his third league goal of the season.
Juventus open up a 12-point lead at the top of Serie A ahead of Napoli.
Palermo has nurtured top players such as Argentine internationals Paulo Dybala and Javier Pastore and Uruguay forward Edinson Cavani.
Cristiano Ronaldo equalised from the spot before blasting home a magnificent second to secure a ninth win in 10 Serie A matches for Juventus.
Juventus have maximum points after three games in Group H, and host Mourinho's side in Turin next.