While Aaron Finch pretty much sealed the match with his superlative effort of 156 from 63 balls, Joe Root's 90 would have caused some flutters in the Aussie camp.
England skipper Alastair Cook along will Stuart Broad, Ian Bell, James Anderson and Graeme Swann have been rested for the lone one-day international against Ireland and the five-match one-day series with Australia that follows. Eoin Morgan will lead the side in Cook's absence.
Bell also backed county colleague Boyd Rankin to impress if given a chance in Wednesday's third one-day international against New Zealand at Trent Bridge.
After Sunday's 86-run humbling loss to New Zealand, England captain Alastair Cook was unsure whether the two seamers would be fit for Saturday's Champions Trophy opener against Australia at Edgbaston.
This latest ODI series victory was just the tonic New Zealand needed after being whitewashed 2-0 by England in the preceding Test series and left them full of confidence heading into the one-day Champions Trophy tournament in the UK that starts on Thursday.
Cook added county experience of playing in different formats would help those players also in the Test squad cope with the change to coloured clothing and two white balls.
Vettori said that during his injury lay-off, he had contemplated retirement but that now his intention was to play in all three international formats and represent New Zealand at the 2015 World Cup which they will co-host with Australia.
Probable teams and officials for the first one-day international between England and New Zealand at Lord's on Friday (0945GMT start):
England will hope he is able to return for the national side in time for the start of the Champions Trophy, which begins four days after the third and final one-day match against New Zealand on June 5 at Trent Bridge.
There couldn't have been a perfect setting for the series finale as Dharamsala can be easily compared with Newlands in Cape Town or the John Davies Oval in Queenstown as one of the most beautiful cricket grounds in the world.