Parupalli Kashyap suffered a 16-21, 18-21 defeat against Sun Feixiang of China.
PV Sindhu took just 39 minutes to record a 21-13, 21-19 win over the world number 22.
Kidambi Srikanth defeated China's Huang Yuxiang 16-21, 21-14, 21-19 to enter men's singles final in the India Open badminton tournament.
Kashyap will be up against Viktor Axelsen in Saturday's semi final, while Srikanth will face China's Huang Yuxiang.
Five singles players and four doubles pairs from India have entered the quarter-finals of the India Open, a BWF World Tour Super 500 tournament.
Subhankar Dey produced the biggest upset of the first day of the India Open, beating World No.9 and fourth seed Tommy Sugiarto of Indonesia.
Saina Nehwal went down 15-21, 19-21 in the 37-minute match against World No.1 Tai Tzu Ying of Taiwan in the quarters of All England Championship.
Saina Nehwal had tied the knot with Kashyap Parupalli on December 14, 2018.
Saina Nehwal Wedding: The World No.10 confirmed the news of her wedding with Parupalli Kashyap in October. Saina and Kashyap have been dating each other for the past ten years.
Parupalli Kashyap and Sania Nehwal wedding will take place on December 16, 2018.
Saina Nehwal and Parupalli Kashyap will tie the knot in December 2018.
Saina Nehwal will next meet Ruselli Hartawan of Indonesia for a place in the final.
Third seed Sameer Verma defeated China's Zhao Junpeng 22-20, 21-17 to enter men's singles quarterfinals.
Kidambi Srikanth, who had reached number one in world badminton rankings, has taken a dip since his loss in 2018 Commonwealth Games final.
Saina Nehwal fell in a first round as she lost to Akane Yamaguchi of Japan in three games.
Parupalli Kashyap shared his ordeal on his official Twitter account on Saturday.
Saina Nehwal said she had started dating Parupalli Kashyap in 2007 after they began going on tours together but delayed the marriage in order to focus on their careers.