Somdev, on the edge of the top-100, lost 2-6, 4-6 to his Slovakia rival, ranked 108, in one hour and 18 minutes.
Since winning Delhi Open Challenger tournament, Somdev has won only one match on the Tour and that too when Juan Martin del Potro had retired mid-way in the Dubai event.
Somdev did win two matches in the Davis Cup early this month but even in those victories the Indian was stretched by the lower-ranked Korea players.
It was a fateful start for the Indian in the euro 2,127,035 clay court ATP 500 tournament, as he was broken in the very first game of the match.
He did put up a fight in the second set but the day just did not belong to him.
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In the doubles, Rohan Bopanna and Aisam-ul-haq Qureshi advanced to the quarterfinal with a comfortable straight sets win over Treat Huey from Philippines and Dominic Inglot from Britain.
The unseeded Indo-Pak pair beat their rivals 6-1 6-4 in just 48 minutes in the first round contest.
Bopanna and Qureshi saved all three break chances they faced and converted three of the four chances they got.
They may face top seeded team of Nenad Zimonjic and Daniel Nestor in the next round.