World number one Novak Djokovic delivered the fatal blow by beating the last American man standing, world number 156 Bobby Reynolds, 7-6 (7/2), 6-3, 6-1 in the second round.

While several of Djokovic's title rivals have fallen foul of the shock defeats and injury withdrawals that have rocked Wimbledon over the last four days, the 26-year-old has progressed serenely to the last 32 and is yet to drop a set.

Juan Martin del Potro celebrated the start of his pre-French Open campaign with a 6-1, 6-0 hammering of Portugal's Rui Machado to reach the quarter-finals of the Estoril Open on Thursday.

Feliciano Lopez, ranked 15th in the world, won his Houston debut on Wednesday, beating Paolo Lorenzi 6-4, 7-6 (7/4) to reach the quarter-finals of the ATP Tour US Men's Clay Court Championship.