Two-time champ Kim Clijsters pulled out of Indian Wells in mid-match with shoulder problems, adding to the growing list of top-seed casualties among the women on Tuesday.
Defending champion Jelena Jankovic and reigning French Open champ Francesca Schiavone were also bounced in the fourth round, leaving just three of the top 10 seeds left 4.5 million dollar WTA Indian Wells hardcourt tournament.
Top ranked Caroline Wozniacki did manage to sneak through, but even she had her work cut out for her as the Dane lost the first set before rallying to beat Alisa Kleybanova of Russia 2-6, 6-3, 6-1 to reach the quarter-finals.
Second seed Clijsters retired from her fourth round match in the middle of the second set with a right shoulder injury, gifting the victory to France's Marion Bartoli.
"I just felt on every serve or forehand that came in a little high that something was not right -- that something was not suppose to be there," Clijsters said.
Clijsters won the first set 6-3 but then called for the trainer early in the second set before packing it in 24 minutes in with Bartoli leading 3-1.
Clijsters had complained of having right shoulder problems this week and has been getting regular treatments for the injury, but it all caught up to her against Bartoli.
"I still felt I could have won," Clijsters said. "I could have taken pain killers but I don't want to risk tearing it and I don't want to be in a situation where I am taking medication to cover something up.
"It makes me realize I am not the youngest out there and maybe I don't recover as fast."
Clijsters said she started to have problems with the arm during the Aussie Open in January. She said she couldn't remember the last time she pulled out in the middle of a match.
"A lot of times it is important to rest and listen to your body even though it goes against what other people might be saying," she said.
Clijsters, who won Indian Wells in 2005 and 2003, ended her streak of reaching the final in her last five tournaments.
Clijsters now heads to Florida to try and get ready for the Miami tournament.
"I need a few days rest and to have some tests done," Clijsters said.
The injury dashes any hope Clijsters had of regaining the world number one ranking at this event. Clijsters needed to post a better finish than Wozniacki in Indian Wells to do that.
Wozniacki moves on to the quarter-finals, where she will face eighth seeded Victoria Azarenka, who beat Agnieszka Radawanska of Poland 4-6, 6-3, 7-6 (7/3).
"It was a tough match," Wozniacki said. "I think I made a bit too many unforced errors.
"Then the second set I just told myself I needed to move my feet a little bit more.
"I need to have a little bit more margin over the net and from the lines, and things started to go my way and I started to play better."
The sixth-seeded Jankovic was attempting to become the first women since Martina Navratilova (1990 and 1991) to defend her title at Indian Wells.
"I just didn't move. I felt really stuck with my feet," said Jankovic, who lost 6-4, 6-2 to fellow Serb Ana Ivanovic. "I wasn't solid with my game. I made some selfish shots, especially in the first set."
"I just didn't really play my tennis, didn't really do what I was supposed to do."
Ivanovic added to the Serbian assault on Indian Wells Tuesday by hitting seven aces and saving six-of-seven break point chances to post her seventh win over Jankovic in 10 career meetings.
"I'm really happy," Ivanovic said. "I played some good tennis in the past few weeks. To play consistent on that level, I'm really pleased."