Edinson Cavani's header eight minutes from time from Jonathan Rodriguez's cross propelled Uruguay above Chile
Edinson Cavani has scored 17 times in the French league and twice in the Champions League this season.
Palermo has nurtured top players such as Argentine internationals Paulo Dybala and Javier Pastore and Uruguay forward Edinson Cavani.
Coach Unai Emery was fired last summer and left for Arsenal after failing to bring the trophy to Paris.
Julian Draxler, Edinson Cavani, Angel di Maria and youngster Moussa Diaby all found the net at the Parc des Princes.
The Paris Saint-Germain striker was forced out of play after an injury in the round-of-16 match.
Uruguay and France are pitted in possibly one of the closest clashes in the quarter-finals.
The mouth-watering last-eight tie in Nizhny Novgorod is likely to be decided by a battle between Uruguay's stifling backline and the speed of Mbappe.
Cristiano Ronaldo will be nearly 38 by the time the next World Cup comes around in Qatar in 2022.
With time running out for trailing Portugal, Ronaldo could have been justifiably angry, frustrated or simply not focused on an injured opponent.
Pepe's goal was the first time the South Americans' defence had been breached in the tournament.
The South Americans take on the hosts in their final Group A match on June 25 with top spot on the line, while Egypt and Saudi Arabia have been eliminated after both suffered back-to-back defeats.
Uruguay would be keen to add three more points when they meet under-fire Saudi Arabia in a World Cup 2018 Group A match.
Jose Gimenez rose to power a header into the top corner and break Egypt hearts.
FIFA World Cup 2018: Egypt vs Uruguay Highlights: Uruguay's deserved last-gasp victory leaves them and Russia in early control in Group A after the hosts' 5-0 mauling of Saudi Arabia in the tournament opener.
Mohamed Salah has been the biggest topic as the Egypt vs Uruguay World Cup match approaches.
After being denied by Monaco last year, there was never really any doubt that PSG would reclaim the Ligue 1 crown this time.
A tearful Neymar pleaded with the media to stop the "false stories" about his alleged frosty relations with PSG coach Unai Emery and fellow striker Edinson Cavani.