The matches will be played at the Guyana National Stadium on Sunday, July 14 and Tuesday July 16.
Guyana will host the first two ODIs, followed by three ODIs at the Beausejour Cricket Grounds in St Lucia. St Vincent will host the two Twenty20 Internationals July 27 and 28 to conclude the tour.
West Indies captain Darren Sammy believes Arnos Vale can prove to be a "happy hunting ground" for his side, which prepares to square off with Australia in the first three One-Day Internationals of the five-match series starting from Friday.