Defending champion Tamira Paszek was forced to retire with a left thigh injury from her first-round match against 2009 champion Caroline Wozniacki at Eastbourne on Tuesday.
Wozniacki was leading 6-2, 2-2 when Paszek was forced off.
The Austrian, who was chasing her first win on the WTA tour since January, was broken at 3-2 and Denmark's Wozniacki then broke again to take the opening set. Paszek broke to lead 2-1 in the second set but then received treatment, lost her next service game and retired.
A single break of serve late in each set gave Australia's Bernard Tomic a 6-3, 6-4 victory over British wild card James Ward.