His semi-final win over Djokovic in the California desert had ended the Serbian star's match winning streak at 22, and del Potro then extended Rafael Nadal to three sets in the final. However, he said losing his opening match in Miami wasn't the result of a let-down, either physical or mental.
Berdych emerged both relieved and disgruntled after surviving 7-5, 6-1 against the world number 90, which carried him laboriously into the quarter-finals of the tournament.
Roger Federer equaled Jimmy Connors' record of 233 career Grand Slam match wins by beating Tobias Kamke of Germany 6-2, 7-5, 6-3 in the first round of the French Open on Monday.
John McEnroe made a brief return to play an exhibition doubles match on the opening night of the SAP Open, teaming with young American Jack Sock to beat Gael Monfils and Steve Johnson 6-4, 6-4 in a lighthearted match on Monday.
Rising Indian tennis player Yuki Bhambri stunned fourth seed Tobias Kamke of Germany in a hard-fought three-setter to enter the second round of the ATP USD 100,000 Challenger Tournament in Dallas, United States.
Fourth-seeded Andy Murray beat Tobias Kamke of Germany 6-3, 6-3, 7-5 on Wednesday to ease into the third round of Wimbledon.
Mischa Zverev of Germany advanced to the second round of the Serbia Open on Monday by beating Israel's Dudi Sela 7-6 (4), 3-6, 6-3. Slovenia's Blaz Kavcic also moved on after beating Tobias Kamke of Germany, 7-6 (0), 6-1.