Eighth-seeded American Isner defeated Alex Kuznetsov 7-6 (7/2), 7-6 (7/4) in the second round.
Rafael Nadal on Monday revealed his Australian Open bid was nearly over before it started after he suffered crippling pain in his troublesome right knee on the eve of his first match.
Spanish second seed Rafael Nadal defeated American Alex Kuznetsov 6-4, 6-1, 6-1 in the opening round of the Australian Open on Monday.