Andy Murray crashed out of the US Open in the fourth round Monday, his earliest Grand Slam exit in five years, while 17-time major winner Roger Federer advanced to the quarter-finals.

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South African 15th seed Kevin Anderson upset British third seed Andy Murray 7-6 (7/5), 6-3, 6-7 (2/7), 7-6 (7/0) Monday at the US Open to reach his first Grand Slam quarter-final. (All AFP photos)

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Kevin Anderson ended a 0-15 career hoodoo against top-10 opponents and an 0-7 hex in fourth-round Slam matches to book a last-eight date with Swiss fifth seed Stan Wawrinka, the reigning French Open champion.

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Wawrinka defeated US left-hander Donald Young 6-4, 1-6, 6-3, 6-4, at Arthur Ashe Stadium.

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Swiss second seed Roger Federer advanced to his 11th US Open quarter-final on Monday by defeating American 13th seed John Isner 7-6 (7/0), 7-6 (8/6), 7-5.

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The 17-time Grand Slam champion will play French 12th seed Richard Gasquet -- who eliminated Czech sixth seed Tomas Berdych 2-6, 6-3, 6-4, 6-1 -- on Wednesday for a semi-final berth.

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Simona Halep overcame injury and 30-degree heat to set-up a last-eight clash against two-time runner-up Azarenka. Halep needed 2hr 38 min, as well as a 10-minute heat break, to down German 24th seed Sabine Lisicki 6-7 (6/8), 7-5, 6-2. Halep, 23, is the first Romanian in the last eight in New York since Irina Spirlea went to the 1997 semi-finals.

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Petra Kvitova became the first Czech to reach the quarter-finals since Daja Bedanova in 2001. Kvitova saw off British qualifier Johanna Konta 7-5, 6-3.

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Victoria Azarenka reached her fourth quarter-final in four years with a 6-3, 6-4 win over Varvara Lepchenko of the United States.

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US Open 2015: Andy Murray Knocked Out, Roger Federer, Simona Halep Advance

Andy Murray crashed out of the US Open in the fourth round Monday, his earliest Grand Slam exit in five years, while 17-time major winner Roger Federer advanced to the quarter-finals.