Chelsea overcame in-form Championship side Derby County 2-0 in the FA Cup third round on Sunday, after West Ham United were thrashed 5-0 by Nottingham Forest.
Derby have won 10 of their 15 league games since former England manager Steve McClaren took over, but they fell to second-half goals from John Mikel Obi and Oscar as Chelsea set up a fourth-round meeting with Stoke City.
Chelsea enjoyed the best of the first half at Pride Park but they were largely restricted to pot shots from distance.
Oscar went close on three occasions, while Ramires saw a low shot come back off the base of the left-hand post in first-half stoppage time.
As Chelsea continued to labour in the second period, manager Jose Mourinho introduced Eden Hazard and Fernando Torres from the bench, and in the 66th minute the visitors made the breakthrough.
Hazard's trickery wide on the left yielded a free-kick and from Willian's wicked, in-swinging cross, Mikel glanced home a header to mark his 300th Chelsea appearance with his fourth goal for the club.
Oscar got on the score-sheet shortly afterwards, gathering a pass from Hazard and beating Lee Grant at his near post with a powerful shot.
Torres should have added a third but after rounding Grant he got the ball caught under his feet, while Ramires also saw a deflected shot skim the bar.
West Ham became the second Premier League team to be eliminated by lower-league opposition in this season's competition when they were crushed by Championship side Forest at the City Ground.
A day after Aston Villa fell to third-tier Sheffield United, West Ham were undone by a 14-minute hat-trick from Forest forward Jamie Paterson, sandwiched by an early Djamel Abdoun penalty and a late Andy Reid strike.
West Ham manager Sam Allardyce made nine changes to his starting XI and gave debuts to three young players, but he told ITV: "What choice did I have? I don't think I had one.
"I make the decisions for the benefit of everyone at the football club. We have a huge amount of problems in terms of available players."
Sunderland overcame third-tier Carlisle United 2-1 at the Stadium of Light to take their place in round four.
Adam Johnson put Sunderland ahead with a 34th-minute free-kick and then supplied the cross from which Sean O'Hanlon put through his own goal after Matty Robson had levelled the scores.
A 90th-minute strike from 20-year-old French midfielder El-Hadji Ba completed victory for Gus Poyet's men.
Liverpool will look to avenge their shock 3-2 defeat by Oldham Athletic in last season's competition when they invite the third-tier side to Anfield later on Sunday.
Meanwhile, David Moyes will take charge of his first FA Cup tie as Manchester United manager when Swansea City visit Old Trafford.