Jeev Milkha Singh and SSP Chowrasia are certain to miss the cut after carding 75 and 73 in the first two rounds of the Irish Open at Carton House on Friday.
The Indian duo were down at four-over for 36 holes, where the cut looked likely at even par.
At the top of the leaderboard, Peter Uihlein and Robert Rock shared the clubhouse lead midway through the second round.
Uihlein has been in good form after winning his first European Tour event at the Madeira Islands Open last month, while Rock had missed six cuts in nine tournaments since finishing tied for seventh in Dubai.
Uihlein, a former US Amateur Champion, had five birdies and a single bogey in his second round 68 to reach nine under par.
Englishman Rock saw off Tiger Woods and Rory McIlroy to win the Abu Dhabi HSBC Golf Championship last year, and returned to that sort of form with four birdies and eagle at the long fourth in his 66.
Overnight leader Oscar Floren was in a tie for third, the the Swede carding a 71 to sit alongside former Ryder Cup captain Jose Maria Olazabal, Joost Luiten and Ricardo Santos on seven under.