World number two and Commonwealth Games gold medallist, Saina defeated Chan 21-16 21-18 in half an hour match in the women's singles event to set up a clash against Salakjit Ponsana of Thailand. Ponsana defeated Hsiao Huan Chen 21-18 21-13 in her first round match.
Among Indian men, CWG bronze medallist P Kashyap also crossed the first hurdle with a gruelling three-game win over Chinese Taipei's Yu Hsing Hsieh in the singles.
The Indian fought past Hsieh 21-14 19-21 21-18 in an hour and four minute encounter. He will next face fifth seed Jin Chen of China on Thursday.
However, disappointment was in store for other two Indians in fray - Aravind Bhat and RMV GurusaiDatt.
While Bhat went down to Tanongsak Saensomboonsuk 13-21 21-23, Gurusaidutt fought his heart before going down 12-21 21-19 13-21 to local favorite Wing Ki Wong.