Hull has five points from four games, with West Ham a point behind in the English Premier League standings.
Uruguay manager Oscar Tabarez had changed his entire starting XI for the South American champions' decisive first round match. Star forwards Diego Forlan, Suarez and Edinson Cavani were all named on the bench, while Bologna midfielder Perez inherited the captain's armband from suspended centre-back Diego Lugano.
Uruguayan forward Abel Hernandez was robbed at gun-point after returning from training with Palermo, Ansa reported.