Di Santo comes with some Premier League experience after spells at Chelsea and Blackburn Rovers as well as Wigan, who were relegated last season.
The home side were on the backfoot but managed to hold out for the draw against Roberto Martinez's men.
Franco di Santo's second-half goal earned Wigan a deserved draw away at fellow Premier League strugglers Fulham on Saturday as an entertaining game ended 1-1.
Wigan Athletic held off promoted Southampton to claim a 2-0 away win on Saturday that took Roberto Martinez's side into the top half of the Premier League table.
Wigan moved off the foot of the Premier League with a gritty come-from-behind 2-1 win at Sunderland's Stadium Of Light on Saturday with Argentina striker Franco Di Santo grabbing the injury time winner.
Argentine striker Franco Di Santo scored either side of halftime to earn Wigan a 2-0 win over promoted Queens Park Rangers and maintain his team's unbeaten record in the Premier League this season.