The Malaysian ace buried 15 smash winners as he sent Santoso packing in just 34 minutes at the season finale in Liuzhou, southern China, after taking three games to beat Japan's Sho Sasaki on the opening day.
China's Chen Long battled back from a game down to beat Japan's Tago Kenichi 12-21, 21-18, 21-13 to also make it two out of two in group play at the $500,000 event.
China's Olympic champion Lin Dan, who is seeking the last major title to elude him, will face Indonesian star Taufik Hidayat in an eagerly awaited clash during Thursday's evening session.
Meanwhile China's top women's seed Wang Yihan recovered from her shock loss to South Korea's Sung Ji-Hyun as she scored a two-games win over Denmark's Tine Baun. Sung beat Juliane Schenk of Germany in the other early women's match.
The World Superseries Finals is the culmination of badminton's annual Superseries, with the top eight in each of the singles and doubles categories playing in a round-robin system to reach the weekend semis and finals.
Lee stays perfect at Superseries Finals
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