Villas-Boas has been handed a fitness boost as England winger Aaron Lennon is ready to return from a knee problem. Jermain Defoe could start after returning from a pelvic injury last weekend, coming off the bench and scoring in the victory over Manchester City.
Wigan's woeful start to the season got worse on Monday as Antolin Alcaraz was charged by the Football Association (FA) with spitting at Wolves defender Richard Stearman during Sunday's 3-1 defeat.
Paraguay coach Gerardo Martino on Wednesday called up Wigan Athletic defender Antolin Alcaraz to reinforce his backline against holders Brazil in the Copa America on Saturday.