PV Sindhu has been playing continuously for the last three weeks, participating in the Denmark Open, French Open and the National Championship in Nagpur.
Newly-crowned national champion HS Prannoy broke into top-10 by jumping a spot in the latest BWF World rankings.
While Saina lost 18-21, 11-21 against Japan's Akane Yamaguchi, world no. 11 Prannoy was stunned by 53rd ranked Cheuk Yiu Lee of Hong Kong 21-19 21-17.
Former World No.1 Saina upstaged Olympic silver-medallist P V Sindhu in the national finals last week to claim her third championship crown, while Prannoy stunned Kidambi Srikanth to clinch his maiden title at the 82nd edition of the event at Nagpur.
Ace shuttler Kidambi Srikanth on Thursday said that Indian badminton is on the rise and much better results will be in the offing if the hard work is sustained.
Second seed Prannoy, who achieved his career-best ranking of World No 11 last week, saw off top seed Srikanth 21-15 16-21 21-7.
World No 2 Kidambi Srikanth and giant-killer H S Prannoy will clash in the men's singles final at the 82nd Senior Badminton National championship
Olympic medallists P V Sindhu and Saina Nehwal sailed into the women's singles semi-finals while men's world number two Kidambi Srikanth also notched up a comfortable win.
Srikanth will have a chance to topple Viktor Axelsen with some good show in the upcoming events at China and Hong Kong.
India's Kidambi Srikanth came back from a game down to beat compatriot HS Prannoy and enter his maiden French Open Superseries final.
French Open Superseries Semi-final Highlights: PV Sindhu crashed out after losing to Akane Yamaguchi, Kidambi Srikanth advanced to final after beating his compatriot HS Prannoy.
Indian shuttler HS Prannoy dumped Denmark's Hans-Kristian Vittinghus in straight games to progress to the men's singles quarterfinals of the French Open Super Series.
Saina Nehwal, H S Prannoy and B Sai Praneeth made it through the opening day unscathed to enter the second round of the USD 325,000 French Open Super Series.
India's Kidambi Srikanth showed sheer class as he beat Denmark's Viktor Axelsen to enter the semi-finals of Denmark Open Superseries.
Just four months back, Prannoy had created a flutter when he dispatched Chong Wei in straight games in the Indonesia Super Series Premier and the unseeded Indian dished out another superb performance on Thursday to oust the former World No. 1 Malaysian 21-17 11-21 21-19 in a match that lasted an hour and three minutes.
Saina, who won a bronze in the Glasgow World Championship, defeated Marin 22-20 21-18 in a hard-fought battle.
Kidambi Srikanth, who lost in the quarterfinals in Japan Open, remains the highest-ranked Indian male player at eighth.
With this victory, Axelsen enjoys a 3-2 head-to-head lead over Srikanth in five meetings, having won the last three duels.