A draw for Atletico could see Real Madrid winning the title if they win their final game, with a better head-to-head record.
Atletico's upcoming opponents Valladolid are fighting for survival, and are currently 19th in the 20-team table. Along with Valladolid, Huesca and Elche are also fighting for survival. Meanwhile, Eibar are already relegated.
Spanish giants Barcelona are already out of the title race, and are third in the standings. Despite a poor season, Lionel Messi will finish as the season's top scorer with 30 goals. The Argentine won't be present for his side's final game of the season.
Villarreal, who will be facing Real Madrid, are also fighting for a Europa League spot and currently seventh with 58 points.
However, Unai Emery's side could get a direct berth in next season's Champions League, if they defeat Manchester United in the Europa League final.
The Europa League final is scheduled for May 27.