Pallikal, the 22-year old from Chennai, will next meet top seed and World No.1 Nicol David from Malaysia who won the title in 2005. The 30-year-old from Penang, eager to make up for a shock quarter-final exit last year, dispatched Australia's Donna Urquhart11-8, 11-5, 11-4.
Brown, the US-based World No.11, started strongly and managed to contain underdog Pallikal's shot selection, winning the first two games.
In the third, Brown led 9-7 before reaching match-ball at 10-9, but was unable to convert it as Pallikal, ranked six places lower, dug in to take the game 13-11.
Pallikal took the fourth to set up a decider. The players traded points in the fifth until 9-9 and Kasey got a no let in the front backhand corner to take the Indian to 10-9 match ball. The Indian took her chance on the first attempt and went through to take the match.
A thrilled Pallikal said after her 6-11, 10-12, 13-11, 11-8, 11-9 victory: "I'm really, really, pleased to get through. When my mum told me I was in the main draw, I didn't believe her as I was thinking that I was going to have to qualify.
"So I wanted to take advantage of being in the main draw. I came all the way to the USA for one tournament as I am playing in Macau, China, in a week's time.
"I had 3 months off tournaments this summer, so I trained with Sarah Fitz-Gerald in Australia, trained with Ritwik (Bhattacharya) in Mumbai and in Chennai with my fitness trainer Basu and I think it made the difference. I'm really thankful to Sarah as she has put a lot of effort in for me and she'll be really pleased that I won today!"
A disappointed Brown said: "I was 2-0 and had match ball in the third! I knew it was going to be tough and I think I went a little defensive in the third and fourth and in the end she was able to pull it out. She played well."
Dipika Pallikal recovers from 2-games down to enter quarters in New York squash
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