It is that time of the year once again when New York gets set to welcome giants of international tennis as they battle each other for supremacy at the Flushing Meadows.
Here are the 'usual suspects' who have the best chance of emerging victorious on the hard-courts here.
All eyes would be on Andy Murray who won the Wimbledon title recently and has grown in strength off late.
He recently said that the hangover from London is long gone and he is ready to defend his US Open title.
Giving him stiff competition would be Novak Djokovic.
The Serb won the title here in 2011 and would be raring to snatch it back this year.
In 2011, Djokovic defeated Rafael Nadal (left) to win the US Open.
Nadal will now be banking on his wins in Rome and the recent victory in Cincinnati to stake his claim to slightly lost glory.
Roger Federer is seeded No. 7 for the US Open, his first slot outside the top three at any Grand Slam tournament in a decade. Does that mean he does not stand a chance?
His fans would scream a big no as their hero gets set to prove that there is no substitute for experience.
Another player who would also be hoping to make most of his rich experience is David Ferrer.
This Spaniard has been there and done a lot of that. He almost always makes it to lists such as these but winners podium has largely eluded him. US Open 2013 may just be the spark he needs.