The No.2 seeds needed just 52 minutes to triumph 6-1, 6-1 to secure their second title together following their Cincinnati Open win.
Sania and Strycova overcame their US Open quarter-final exit and looked completely at ease during the final on Saturday.
This is Sania's third Pan Pacific Open title in four years. Having won the tournament in 2013 and 2014 with Cara Black. The 29-year-old had given the tournament in Tokyo a miss last year.
The Indo-Czech pair took just 26 minutes to clinch the first set 6-1. They sped to a 5-0 lead and never looked back.
The second set started in a more even note with the scores tied 1-1 with the second seeds' serve coming under a little pressure.
However, Sania and Barbora took the next five games to take the set 6-1 to romp to the title in Tokyo.