Tottenham missed the chance to move into the Premier League's top four after a 1-1 draw at West Ham, while Newcastle were also held 1-1 by Everton on Tuesday.
Eddie Howe's men are languishing in 10th place in the Premier League with 10 games to go and any hope of the club's first major trophy since 1969 is over for another year.
Bernardo Silva scored twice as Manchester City beat Newcastle 2-0 to reach the FA Cup semi-finals on Saturday, while Coventry struck twice in stoppage time to stun Wolves 3-2.
Manchester United are aiming to derail Liverpool's bid for a quadruple and salvage a difficult second season for Erik ten Hag in Sunday's FA Cup quarter-final.
Mauricio Pochettino called for the Chelsea fans to trust his players after a 3-2 win over Newcastle on Monday propelled the Blues back into contention for European football next season
Arsenal's free-scoring Premier League form continued as Newcastle were blown away 4-1 at the Emirates on Saturday to move back within two points of leaders Liverpool.
Manchester City can move within one point of Jurgen Klopp's team if they win their game in hand at Bournemouth, while Arsenal must beat Newcastle to stay in touch with the title pacesetters.
Newcastle are up to seventh place as they try to salvage European qualification from a difficult season.
Pep Guardiola said Manchester City showed the heart of champions to fight back to beat Newcastle 3-2 on Saturday thanks to a Kevin De Bruyne masterclass on his return to Premier League action.
Manchester City trail Premier League leaders Liverpool by five points, with a game in hand.
Manchester City trail Premier League leaders Liverpool by five points, making their trip to face Newcastle United a crucial moment in the season.
Newcastle had lost six of their previous seven clashes with Sunderland, but their composed display neutered the fired-up Black Cats and delivered a first derby success since a 1-0 victory in 2011.
Newcastle ended their 13-year wait to beat bitter rivals Sunderland as Alexander Isak's double inspired a 3-0 win in the FA Cup third round on Saturday.
Mohamed Salah scored twice as Liverpool stretched Newcastle's miserable run with a 4-2 victory at Anfield to open up a three-point lead at the top of the Premier League on Monday
Manchester City are fourth in the Premier League table but every other side at the top know they are still the team to beat.
Chelsea came back from the brink to reach the League Cup semi-finals with a dramatic penalty shoot-out victory against Newcastle after Mykhailo Mudryk's last-gasp equaliser on Tuesday.
Manchester City threw away a 2-0 lead against Crystal Palace in Premier League.
PSG drew 1-1 away to Group F winners Borussia Dortmund to go through as runners-up after AC Milan came from behind to beat Newcastle at St James' Park and eliminate Eddie Howe's side.