Youzhny, ranked 33rd and winner of eight ATP titles, defeated
Fognini led 4-1 before dropping serve in the third. He held on and became the first Italian champion in Stuttgart.
The 31-year-old Swiss swept to a 6-3, 6-2, 6-0 win on Centre Court to celebrate the 10th anniversary of his first triumph at the All England Club with an impressive triumph.
On Tuesday, he dropped the first two sets against Romania's Victor Hanescu before quitting in the third set to hand a 7-5, 7-6 (9/7), 2-1 win to his opponent.
Ferrer, who has not played here since 2009, took nearly two hours to subdue his feisty French opponent, serving four double-faults and being broken three times.
Bhupathi and Nestor beat Romanian Victor Hanescu and Slovak Martin Klizan with a 6-1, 7-6 (8), while Bopanna and Ram lost to Italians Simone Bolelli and Fabio Fagnini with 2-6, 6-7 (3).
Nishikori had some trouble with his knee and had to call out the ATP trainer. He however managed to eventually go past his opponent.
Bernard Tomic was badly beaten in the first round for a third straight tournament, with the Australian number one shunted out of the Swiss Indoors 6-0, 6-2 on Tuesday by Mikhail Youzhny.
Eighth-seeded Gilles Muller from Luxembourg beat Lukas Lacko of Slovakia 6-0, 4-6, 6-3 in their first matchup in their Serbia Open debut on Tuesday.
Rising star Milos Raonic of Canada breezed into the quarter-finals of the ATP Chennai Open with a 6-1, 6-4 win over Victor Hanescu of Romania on Wednesday.
Juan Carlos Ferrero overcame a long rain delay on Sunday to defeat Pablo Andujar 6-4, 6-0 in an all-Spanish final of the Mercedes Cup.
Juan Carlos Ferrero beat Marcel Granollers 6-4, 6-3 in an all-Spanish showdown to reach the semifinals of the clay-court Mercedes Cup on Friday.
Juan Carlos Ferrero knocked out the last remaining seed at the Mercedes Cup when he beat No. 3 Mikhail Youzhny 6-7 (6), 6-2, 6-2 in the second round on Thursday.
Victor Hanescu of Romania saved two match points before beating top-seeded Gael Monfils 2-6, 7-6 (7), 6-4 in the first round of the Mercedes Cup on Wednesday.
Santiago Giraldo of Colombia upset second-seeded Jurgen Melzer of Austria 6-4, 7-5 on Tuesday to advance to the second round of the Mercedes Cup.
German wild card Cedrik-Marcel Stebe celebrated his first victory on the ATP tour when he upset sixth-seeded Nikolay Davydenko of Russia 3-6, 6-1, 6-4 in the first round of the Mercedes Cup on Tuesday.
Three-time Wimbledon runner-up Andy Roddick moved into the third round on Wednesday by beating Victor Hanescu 6-4, 6-3, 6-4.