Venus Williams of the United States shakes hands at the net with Angelique Kerber of Germany after their women's second round match. The bigger of the Williams sisters was knocked out in the second round by the German. (All AFP Photos)
Venus's sister Serena Williams did not have any troubles though as she beat Maria Jose Martinez Sanchez of Spain in straight sets to advance.
Czech player Tomas Berdych too cruised into the third round with a runaway victory over Jurgen Zopp.
Jo-Wilfried Tsonga of France during a changeover in his match against Martin Klizan of Slovakia. Tsonga could not go past the second round and was handed a 4-set loss by unknown Martin Klizan, who is ranked 52 against the Frenchman's 6 in the ATP rankings.
The five time US Open champion Roger Federer had little trouble in brushing Bjorn Phau aside en route to round 3 at the Flushing Meadows.
Ana Ivanovic sailed past Swedish player Sofia Arvidsson to book a third round place at the US Open 2012.
Maria Kirilenko, who has looked consistent over the past few months, too breezed into the third round after a straight sets victory over Greta Arn.