2011 champion and world No.1 Novak Djokovic brushed aside Lithuanian 112th-ranked Ricardas Berankis 6-1, 6-2, 6-2.
With victory over Grega Zemlja, Roger Federer matched South African Wayne Ferreira for the all-time record run of Grand Slam starts with 56.
Victoria Azarenka had time for a dance during a double-bagel of German Dinah Pfizenmaier.
The shock of the day was the ouster of 2011 champion Sam Stosur, who was stunned 5-7, 6-4, 6-4 by American 17-year-old Victoria Duval.
Born to Haitian parents, Duval was held hostage by gunmen as a young child. Roared on by the Louis Armstrong crowd, she sent the 11th seed packing.
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