London:American sixth seed Andy Roddick was knocked out of Wimbledon in the second round on Thursday by Serbia's Janko Tipsarevic who won 6-7 (5/7), 7-5, 6-4, 7-6 (7/4).
Roddick, the runner-up in 2004 and 2005 to Roger Federer, slumped to his worst defeat in nine visits to the tournament.
Tipsarevic, who now faces Russia's Dmitry Tursunov for a place in the last 16, also rode to the rescue of Serbian men's tennis a day after third seed Novak Djokovic was knocked out by Marat Safin.
Roddick only returned to the tour at Queen's last week after a shoulder injury cut short his claycourt season and his lack of sharpness told in this gruelling three-hour match where he failed to convert any of his eight break points.
Despite firing down 27 aces, he was unable to convert three set points which would have taken the second roud tie into a decider.
Tipsarevic, who wears tinted glasses on court, celebrated victory by collapsing to the turf as he avenged his defeat to the American in the first round here two years ago.