The fourth seeded Indo-Pak pair overcame stiff resistance from Arnaud Clement and Jonathan Erlich before scoring a 3-6 7-6(4) 14-12 win the quarter-finals of the USD 619,500 hard court event.
Bopanna and Aisam now have an uphill task to reach their second consecutive final as they face top seeds and most formidable pair of Mike and Bob Bryan, who beat Latavian Ernests Gulbis and Dmitry Tursunov of Russia 7-5 6-3.
Bopanna and Aisam had ended runners-up at last week's Atlanta Tennis Championships.
Their only title win came in February in Johannesburg.
Somdev Devvarman had lost in the second round of the singles event earlier.