Cristiano Ronaldo opened the scoring for Madrid as he chipped home Mesut Ozil's through ball after just 9 minutes.
Karim Benzema silenced his critics with a well taken effort at the half-hour mark.
Wesley Sneijder was a bitter disappointment for the Turkish side and was substituted at half-time.
The tie was virtually killed off 17 minutes from time after substitute Gonzalo Higuain headed home Xabi Alonso's free-kick.
It was a night of contrasting fortunes for Ronaldo and Didier Drogba, with the Ivory Coast striker unable to influence the game.
Borussia Dortmund were left to rue a host of missed chances as the quarter-final first leg against Malaga at La Rosaleda ended in a 0-0 draw.
Dortmund remain the only unbeaten team in the Champions League this season, while Malaga extended their unbeaten home record in Europe to 14 games.
Delhi dasher is now number 2 in ICC ODI Batting rankings.
Sunil Gavaskar's sister accuses BCCI of being indifferent to women's cricket.
No sign of fitness woes bogging the veteran down.
No pain, all gain!
Man arrested for flying drone plane over City stadium.
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