Spanish striker Fernando Torres - sporting a face mask to protect a broken nose - scored twice as Chelsea beat Rubin Kazan 3-1 in the first leg of their quarterfinal tie.
Juan Mata starred for Chelsea at Stamford Bridge as Chelsea will take a comfortable two-goal advantage to Russia for the second leg.
Gylfi Sigurdsson levelled for Tottenham against Basel, in a match that finished 2-2 after Spurs found themselves two goals down.
Tottenham suffered a potentially serious setback as Gareth Bale was stretchered off with an ankle injury in the final moments of the tie.
Newcastle are very much up against it in the second leg, following a 3-1 defeat to Benfica in Lisbon.
Former Liverpool striker Dirk Kuyt scored the second for Turkish club Fenerbahce, who beat Lazio 2-0 in Istanbul.
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